Три вопроса да, тут есть, что бы сделать хорошие отдельные вопросы, но вместе это много, чтобы покрыть в один ответ. Сканирование DEXA можно измерить брюшной жир Астме всегда присутствует, даже если вы не чувствуете никаких симптомов. Вы получите только симптомы, когда дыхательные пути узкие, из-за некоторых курок, но системного воспаления дыхательных путей фактически всегда присутствует. Это может измениться только на очень длительных временных масштабах. Лекарства могут уменьшить это воспаление. Поэтому неразумно приписывать изменения в симптомах астмы становится лучше или хуже и изменять лекарства на основе этого.

Нейролептики вызывают повышение пролактина, блокируя активность дофамина в Д2 рецепторов (1). Присутствие дофамина на эти рецепторы, подавляет секрецию пролактина (2). Точный уровень высоты пролактина колеблется между нейролептик с антипсихотическим на основе их сродством к D2-рецепторами (2).

Толерантность может развиваться в данном конкретном побочный эффект при хроническом антипсихотические терапия (т. е.: он может стать менее выраженным с течением времени) (1). Уровень пролактина вернуться к базовой линии в течение 2-3 недель после прекращения нейролептик (1).

Долгосрочные последствия для здоровья гиперпролактинемии

Повышенный уровень пролактина может вызвать другие побочные эффекты, такие как плотность костной ткани уменьшается (1)(2). Однако представление о том, что это конкретное событие происходит в результате гиперпролактинемии является спорным, и может возникать и по другим причинам, таким как факторы образа жизни (1)(2). Снижение плотности костной ткани увеличивает риск переломов костей. Переломы позвоночника или бедра вызывают большое беспокойство, потому что они могут привести к инвалидности и высокому риску смерти (3).

Гиперпролактинемия связана с гипогонадизмом (2). Гипогонадизм может предотвратить нормальное развитие в период полового созревания (4).

У женщин есть некоторые опасения, что гиперпролактинемия может увеличить риск рака молочной железы (2). Хотя эта идея тоже спорная (1)(2).

Ссылки

  1. Гиперпролактинемия и Антипсихотической терапии при шизофрении http://www.medscape.com/viewarticle/468929_4
  2. Гиперпролактинемия с антипсихотики http://www.medsafe.govt.nz/profs/PUarticles/hyperpro.htm
  3. Остеопороз - симптомы и причины http://www.mayoclinic.org/diseases-conditions/osteoporosis/symptoms-causes/dxc-20207860
  4. Мужской гипогонадизм http://www.mayoclinic.org/diseases-conditions/male-hypogonadism/symptoms-causes/dxc-20248457
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